Short bio
Ingénieur polytechnicien, École polytechnique (Palaiseau)
MPhil in Computational biology, University of Cambridge (UK)
Thesis title
Combine artificial intelligence with high resolution microscopy to better dissect the mechanism of binding and mechanism of action of multi-specific biologics.
Short abstract
Photo-activated localization microscopy (PALM) enables high-resolution recording of single proteins trajectories in live cells, thus providing precious probes of small-scale properties of the protein environment. I use graph neural networks to characterize relevant physical properties of these dynamics, and developed a flexible analysis scheme able to deal both with the diversity of motion types encountered in nature and with the fact that observed trajectories inevitably differ, to some extent, from archetypal theoretic models.